Powdersville is conveniently located at the northern tip of Anderson County in South Carolina, 8 miles Southwest of the largest city in the region, Greenville. Since it is unincorporated, its boundaries are not well defined; however, It is surrounded by Pickens County (Northwest Border) the Saluda River (Northeast border) and Interstate 85 (Southeast border). Powdersville can be accessed from Interstate 85, a six-lane highway, via exits 39 and 40.
Once known mainly as a farming community, Powdersville has shown unprecedented growth incorporating a multitude of housing subdivisions and businesses along Highway 153.
According to the United States Census Bureau:
- Total: 14.0 sq mi
- Land: 13.9 sq mi
- Water: 0.1 sq mi
- Population (2010)
- Total: 7,618
- Density: 549/sq mi